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KMID : 0351619710120010067
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Kyungpook Medical Journal
1971 Volume.12 No. 1 p.67 ~ p.72
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The Effect of Branched Amino Acid on the Metabolism of Isoleucine
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Abstract
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To study the metabolic interrelationships of branched amino acids, the effect of I,-leucine and L-valine on the metabolism of loadings of L-isoleucine-I´C, incorporation into proteiins and conversion to 1~C0~, were studied in rats.
Administration of 200mg L-leucine per 100g of body weight by means of stomach tube 20 :minutes prior to the injection of L-isoleucine-IBC ~~esulted in a significant increase in I~CO~ expired. It had been previously observed that the maximum absorption of the concentrated amino acid given by stomach tube was 20 minutes slower than that of intraperitoneally injected radioactive amino acid.
The significant increase in I~CO~ production was not observed in rats given the same amount of leucine 12hrs. after the injection of L-isoleucine-IBC.
Incorporation rates of L-isoleucine-IaC into liver and serum proteins, on the other hand, were significantly decreased in the leucine pretreated rats, but the activity of non-protein-IBC in serum, liver and kidney was not affected by the leucine administration.
When rats were given a Ioad of L-valine, another branched amino acid, the metabolism of isoleucine was not singnificantly altered.
The effect of I-glutamic acid and L-aspartic acid, which are active amino acids in tissue transamination reaction, were also studied and no remakable change in the metablism of isoleucine vas found.
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